Text mining for molecular network-based candidate gene prediction

Seminar: 
Applied Mathematics
Event time: 
Tuesday, October 12, 2004 - 12:15pm to Monday, October 11, 2004 - 8:00pm
Location: 
AKW 200
Speaker: 
Michael Krauthammer
Speaker affiliation: 
Yale (Department of Pathology)
Event description: 

There is an increasing interest in integrating literature information on molecular-level processes (such as published research results on molecular interactions between genes, proteins and other entities) with other types/sources of information (such as genetic linkage information). Given the ever-growing size of the biomedical literature, much research has been devoted to automate the parsing and extraction of research results from scientific articles. I will first discuss our experience with working on an automated text mining pipeline for extracting molecular network information from the literature. In a second part, I will be presenting our research on network-based data modeling and analysis: Using Bayesian inference models and Markov Chain Monte Carlo (MCMC) techniques to explore properties of molecular network information, and developing graph-based approaches for pinpointing (genetic linkage-derived) disease genes in molecular networks.